WHO Classification of Genetic Tumour Syndromes: Second Editorial Board Meeting

27 Sept 2022, 18:00 → 30 Sept 2022, 23:00 Europe/Paris

Salon Esteron and Vesubie room (Hotel NH Nice)

Ian Cree (International Agency for Research on Cancer)

Welcome to the second Editorial Board Meeting for the Genetic Tumour Syndromes volume!

After 2 years of virtual meetings, the WHO Blue Books team is very pleased to announce that the second Editorial Board Meeting for the Genetic Tumour Syndromes volume of the WHO Classification of Tumours series (WHO Blue Books) 5th edition will be organized as an in-person event and we are eager to welcome you at the Hotel NH Nice, in the south of France, in Nice, from 27 to 30 September 2022.

While we hope that everyone will join us in-person for this year's meeting, we understand that travel might be difficult for some of you. Therefore, the WHO Blue Book team will provide live access via Zoom to our sessions online for all participants who cannot travel and join us in Nice.

 

Please do check this website regularly as this is where all new information related to the meeting will be shared 😉

 

 

                                                                                               

 

 

 

 

 

Agenda_Genetics_EB 2_27-30 Sept 22_Rev2.pdf

List of Participants_Genetics_EB #2_27-30 Sept 22_rev2.pdf

Tuesday, 27 September

18:00 → 19:00 Registration

collect of supporting documents

Conveners: Asiedua Asante (IARC), Anne-Sophie Bres (IARC)

19:30 → 22:00 Welcome mixer

Dress code is casual

Wednesday, 28 September

09:00 → 09:15 Welcome

Convener: Ian A. Cree

09:15 → 09:45 Introduction

Convener: Ian Cree (IARC)

09:45 → 10:30 General discussion, order of classification of categories, family headings and syndromes: Introduction

10:30 → 11:00 Coffee break

11:00 → 13:00 Chapter 1: Growth factor receptors and related signalling pathways

1.1 Growth factor receptors
1.2 RASopathies
1.3 PKA signalling pathway
1.4 G-coupled proteins
1.5 Transcription factors
1.6 WNT/TGFbeta pathway
1.7 BMP pathway
1.8 Hedgehog signalling pathway
1.9 NF-kB signalling pathway

Conveners: Y. Akkari, M. Arends, A. Gill, A. Lazar, K. Leite, S. Pfister, B. Rekhi, M. Rubin, Dr A. Scarpa, P-H Tan, L. Thompson, M-K. Washington

13:00 → 14:00 Lunch buffet

14:00 → 16:00 Chapter 1: Growth factor receptors and related signalling pathways

1.1 Growth factor receptors
1.2 RASopathies
1.3 PKA signalling pathway
1.4 G-coupled proteins
1.5 Transcription factors
1.6 WNT/TGFbeta pathway
1.7 BMP pathway
1.8 Hedgehog signalling pathway
1.9 NF-kB signalling pathway

Conveners: Y. Akkari, M. Arends, A. Gill, A. Lazar, K. Leite, S. Pfister, B. Rekhi, A. Scarpa, M. Rubin, P-Y Tan, L. Thompson, M-K. Washington

16:00 → 16:30 Coffee break, group photo

16:30 → 18:00 Chapter 8: Other (to be classified)

8.1 RNA splicing
8.2 Spermatogenesis
8.3 Inborn errors of metabolism
8.4 Translation

Conveners: W. Foulkes (remotely), A. Lazar, Z. Liang (remotely), B. Rekhi, B. Rous (remotely)

19:30 → 22:00 Group dinner

Menu:
Dress code: Casual

Thursday, 29 September

08:30 → 10:30 Chapter 5: Oxidative stress response /metabolism

5.1 Von Hippel-Lindau syndrome
5.2 Krebs cycle

Conveners: J. Hodge, M. Rubin, M. Walsh (remotely)

The Journal of Pathology - 2021 - Leske - A common classification framework for histone sequence alterations in tumours an.pdf

10:30 → 11:00 Coffee break,

11:00 → 13:00 Chapter 3: Altered genomic stablity / DNA repair

3.1 Mismatch repair
3.2 Homologous recombination
3.3 Base excision repair genes
3.4 Deficient nucleotide excision repair (NER) of DNA damage
3.5 Non-homologous end joining (NHEJ) and Double strand break (DSB) repair
3.6 Chromosome spindle-related syndromes

Conveners: Y. Akkari, M. Arends, J. Hodge, J. Khoury, A. Lazar, S. Plon

13:00 → 14:00 Lunch buffet

14:00 → 15:30 Chapter 4: Epigenetic drivers and chromatin remodelling

4.1 DICER1 syndrome
4.2 Histone and DNA methylation
4.3 Histone acetylation
4.4 Hippo pathway

Conveners: M. Arends, W. Foulkes (remotely), A. Lazar, B. Rekhi, H. Moch (remotely), M. Walsh (remotely), M-K. Washington

15:30 → 16:00 Coffee break

16:00 → 17:00 Chapter 2: Apoptosis or cell cycle

2.1 P53 pathway
2.2 RB pathway
2.3 MTOR pathway

Conveners: Y. Akkari, A. Gill, S. Pfister, L. Thompson, M. Walsh (remotely)

19:30 → 22:00 Group dinner

Itinerary: https://goo.gl/maps/ktDo76LKYkeRkyjA6

Friday, 30 September

09:00 → 10:30 Chapter 6: Haematopoietic modifers - transcription factors

6.1 Development and maturation of B cell syndrome
6.2 Development of T and B cells

Conveners: Y. Akkari, J. Khoury

10:30 → 11:00 Coffee break

11:00 → 12:45 Chapter 7: Immortalization (Telomere syndromes)

7.1 Telomere maintenance
7.2 Protein metabolism (ubiquitin pathway)

Conveners: Y. Akkari, A. Lazar

12:45 → 13:45 Lunch buffet

13:45 → 15:30 Revisit sections needing further discussion

15:30 → 16:00 Coffee break

16:00 → 17:00 Conclusions, next steps

19:30 → 22:00 Dinner