In 2020, approximately 314,000 women were diagnosed with ovarian cancer and 207,000 deaths. The aim of the study is to provide a comprehensive assessment of the incidence of epithelial ovarian cancer (EOC) by histological subtypes and compare EOC survival across seven high income countries involved in the ICBP-SurvMark-2 project, (Australia, Canada, Denmark, Ireland, New Zealand, Norway, and...
Background: Alcohol use is causally linked to multiple cancer sites. We present global, regional and national estimates of alcohol-attributable cancer burden in 2020 to inform alcohol policy and cancer control across different settings globally.
Methods: In this population-based study, we calculated population attributable fractions (PAFs) using relative risk estimates and alcohol...
Background. A single HPV test is highly sensitive for precancerous cervical lesions but has limited specificity leading to unnecessary referral. We aimed to evaluate the performance of short-term repeat HPV testing, semi-quantitative HPV viral load, and HPV16/18 genotyping for triage of HPV positive women in the ESTAMPA study. Methods. ESTAMPA is a multicentric study across Latin...
Introduction
Cervical cancer is the fourth most frequently occurring cancer in women around the world, most of cases occurring in low‑ and middle‑income countries. High risk human papilloma virus (HR-HPV) DNA test is highly sensitive to detect cervical intraepithelial neoplasia grade 2 or worse (CIN2+). However, the specificity is limited as HPV infections are very common and the majority...
Esophageal squamous cell carcinoma (ESCC) has distinctly high incidence rates in Malawi and Tanzania and much of East Africa, with an adverse prognosis and ill known etiology. Consumption of hot food/beverage, a probable carcinogen to humans, is associated with increased ESCC risk in other settings. We conducted a case–control study in Blantyre, southern Malawi and the Kilimanjaro region,...
Objectives
Malignant Pleural Mesothelioma (MPM) is a rare cancer of the pleura, primarily attributed to occupational asbestos exposure. Despite the world-wide reduction in asbestos exposure through legislation prohibiting its use, the incidence of asbestos-related cancers such as MPM continues to rise in many countries, in part due to the long latency period between exposure and tumour...
Background
International benchmarking studies on cancer survival is an important aspect in cancer surveillance and plays a key role to develop and assess early-detection strategies, the quality of clinical care, and the management of cancer patients.
The International Cancer Benchmarking Partnership (ICBP) SURVMARK-2 is a global, multidisciplinary partnership of clinicians, academics, and...
Metabolomics is a promising molecular tool to identify novel etiologic pathways leading to cancer. Using a targeted approach in a prospective setting, we previously identified associations between 8 circulating metabolites (acetylcarnitine (positive association), arginine, asparagine, phosphatidylcholines (PCs) aa C36:3, ae C34:2, ae C36:2, ae C36:3 and ae C38:2 (negative associations)) and...
Introduction: Chronic diseases frequently pre-exist among individuals with cancer and these comorbidities have been hypothesized to affect survival following cancer diagnosis. We investigated associations between pre-existing cardiometabolic comorbidities and all-cause and cancer-specific mortality among individuals with cancer.
Material and method: 26,987 men and women enrolled in the...
