Objective: To investigate the contribution of socioeconomic inequalities in the incidence and mortality of seventeen major cancer types and to compare the results across European countries.
Methods: The study will use the prospective multi-centric EPIC cohort data with an average follow up period of 14.1 years. Participants include 476,160 men and women free of major chronic diseases at...
Introduction: Some lung cancer screening guidelines recommend using individualized risk
models to refer ever-smokers for screening. However, different models select different screening populations. The leading risk models were developed and validated in Western populations, and almost exclusively in non-Hispanic whites. Hence, there is an almost complete lack of evidence to support the...
Background: Statistically significant associations between papillary thyroid cancer (PTC) and specific common single nucleotide polymorphisms (SNP) in MGMT (rs2296675), promotor region of FOXE1 (rs1867277) and ATM (rs1801516) genes were reported in Belarusian children exposed to Iodine-131 (131I) after the Chernobyl nuclear power plant accident. We further pursued genetic determinants...
Background: There is strong evidence that the use of pesticides increases the risk of hematological malignancies, but associations with Hodgkin lymphoma remain poorly understood. Here, we report associations between Hodgkin lymphoma incidence and the use of 22 pesticide active ingredients and 13 chemical groups (organophosphate, carbamate, organochlorine, and pyrethroid insecticides;...
Background
Agricultural use of carbamate insecticides and risks of non-Hodgkin’s lymphomas (NHL) have been linked in some but not all occupational epidemiologic studies. Moreover, studies on associated risks of NHL by histological subtype of NHL and by type of carbamate insecticides used are scarce.
Objectives
We evaluated the effects of carbamate insecticides on the risks of NHL and...
Introduction: Acylcarnitines (ACs) play a key role in the transport of fatty acids in the cell and in energy metabolism. Their concentrations in blood have been associated with risk of diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have been shown to influence AC concentrations but a more detailed knowledge of their determinants is needed.
Methods: Fifteen and...
Only half of the global deaths in 2010 could be associated with known risk factors, namely smoking, alcohol, diet, environmental factors. It remains critical to build understanding around the remaining half of deaths occurring worldwide, and to identify other risk factors currently unknown or underestimated.
As a rule, extensive questionnaires are utilized to outline lifestyle and...
Background
The association between dietary fat intake and breast cancer risk has been a source of controversy with conflicting results reported in past decades. Additional prospective studies that objectively measure circulating levels of fatty acids are now needed to better understand the associations between dietary fat and breast cancer development.
Methods
We assessed the relation...
Background Robust age-specific estimates of anal human papillomavirus (HPV) and high-grade squamous intraepithelial lesions (HSIL) in HIV-positive and HIV-negative men can inform anal cancer prevention efforts.
Methods We reanalysed individual-level data from 62 studies totalling 29,238 men across four groups: HIV-positive men who have sex with men (MSM), HIV-negative MSM, HIV-positive men...
Background: Pulmonary carcinoids are rare and understudied diseases that account for 1-2% of all invasive lung malignancies. Recently, we performed the first multi-omics characterization of atypical carcinoids, unveiling the existence of the supra-carcinoids and providing the missing pieces for a complete characterization of lung neuroendocrine neoplasms. Aims: We are now aiming at...
Epigenetic regulator genes (ERGs) are a group of over 400 genes which regulate gene expression by DNA methylation, histone modification and chromatin remodeling. ERGs play a crucial role in the establishment and maintenance of cell identity and genome integrity in health and disease. Indeed, ERGs are found to be commonly altered in cancer. This was further confirmed and extended by our...
