Background: Among chronic non-communicable diseases, cardiometabolic diseases and cancer are the leading causes of morbidity and mortality worldwide. Shared risk factors and population aging contribute to an increased lifetime risk of an individual to concomitantly develop cardiometabolic diseases and cancer, resulting in multimorbidity. Multimorbidity can impact cancer screening and may...
Background and objective
Diet could be a risk factor for several cancers, even breast cancer. Dietary patterns reflect the overall diet as it considers the associations between food items and nutrients. However, there is a lack of studies assessing the mechanisms that play a role in the associations of dietary patterns and cancer. The main objective is to develop a protocol to identify,...
Evidence suggests that increased and excess fat mass, adiposity, is associated with increased colorectal cancer risk. There is also evidence that concentrations of many circulating proteins are altered in individuals with adiposity and colorectal cancer. Whether these proteins mediate the association between adiposity and colorectal cancer is not clear.
We use two-sample Mendelian...
Research on cancer, one of the most lethal diseases in the world today, is an expensive, complex process, usually carried out manually in laboratories. In this publication, we present CanGraph, a software solution that allows its users to annotate and interpret unknown metabolites by making use of five pre-existing databases (HMDB, SMPDB, DrugBank, ExposomeExplorer and Wikidata) and five...
Although alcohol is recognized as a type 1-carcinogen, prospective studies evaluating the association between alcohol consumption and the risk of pancreatic cancer (PC) have generally faced power limitation to generate consistent evidence among never smokers. Here, we evaluated the association as part of the Diet and Cancer Pooling Project, a large international consortium of prospective...
