Background: Cancer is a major and growing public health problem in both developed and developing countries. The International Agency for Research on Cancer (IARC) has estimated there are over 19 million new cases and 10 million cancer deaths worldwide in 2020. The greatest impact of the rising cancer burden will occur in less developed countries, where four-fifths of the world's population...
Background: The neuroblastoma burden varies considerably between countries, likely reflecting inequalities in cancer services. Here we evaluated global differences related to neuroblastoma incidence in children.
Methods: We used the database of the International Incidence of Childhood Cancer study (IICC-3) to analyse global variations in neuroblastoma and peripheral nervous tumours incidence...
Background: Breast cancer is the most common cancer in females worldwide. Stage at diagnosis is an important prognostic factor with early-stage patients generally having a better survival than patients diagnosed with late stage. Despite this, little evidence exists about breast cancer survival by stage at diagnosis in transitioning countries.
Purpose: The aim of this study is to explore...
Background: Tobacco smoking is a major cause of disease burden worldwide and can increase the risk of at least 15 different cancer types. To date, the global impact of tobacco smoking on cancer incidence has not been estimated.
Aims: To calculate the global, regional, and national burden of cancer in 2020 attributable to tobacco smoking to inform tobacco policy and cancer control...
Background:
Central nervous system tumours (CNS) represent 20% of childhood cancers. Among them, up to 40% are non-malignant (nmCNS). Untreated nmCNS are life threatening. We analysed registration practices of childhood CNS in population-based cancer registries to highlight the importance of registration of nmCNS.
Methods:
Tumours classified as intracranial and intraspinal in the...
Background: Information collected by population-based cancer registries is crucial for estimating cancer burden indicators and planning cancer control policies. Within the Cancer Risk in Childhood Cancer Survivors (CRICCS) study we aimed to assess the ability of registries to collect data needed to conduct comparative studies of childhood cancer prevalence and risk of second primary neoplasms...
Purpose: We compared the median ages at diagnosis for the four most common cancer types (lung, colon, female breast, and prostate cancers) across different countries worldwide after removing differences due to variation in population age distributions.
Methods: We analyzed the Cancer Incidence in 5 Continents (CI5) Volume XI database, including cancer registries in 63 countries during...
Background: Breast cancer is the most commonly diagnosed cancer and the most frequent cause of cancer death globally. Though prognosis is good in high-income countries, there is an urgent need to improve survival in sub-Saharan Africa, where 3-year survival can fall below 50%. Within these settings, geospatial barriers contribute to delays in diagnosis, but their impact on survival is not...
Cervical cancer screening is the third most common cancer among women. Though evidence showed the high effectiveness of population-based screening programme in reducing the burden of this disease, only 20 out of 28 European Union Member States reported to have population-based screening programme in place in 2017. It is well known that many of the existing programmes in Europe are poorly...
Objectives: Reproductive characteristics are well-established risk factors for breast cancer but their impact on survival has not been studied yet in Sub-Saharan Africa (SSA).
Methods: In this setting, we examined the influence of reproductive factors on survival after a breast cancer diagnosis using data from the African Breast Cancer – Disparities in Outcomes cohort study. In a...
BACKGROUND
Excess body fatness is an established risk factor for postmenopausal breast cancer. Higher insulin levels are also associated with an increased risk of postmenopausal breast cancer, however, whether women with high body fatness but with normal insulin sensitivity or those with normal body fatness who have high levels of insulin are at elevated risk of breast cancer is not known. We...
Background: Among chronic non-communicable diseases, cardiometabolic diseases and cancer are the leading causes of morbidity and mortality worldwide. Shared risk factors and population aging contribute to an increased lifetime risk of an individual to concomitantly develop cardiometabolic diseases and cancer, resulting in multimorbidity. Multimorbidity can impact cancer screening and may...
Background and objective
Diet could be a risk factor for several cancers, even breast cancer. Dietary patterns reflect the overall diet as it considers the associations between food items and nutrients. However, there is a lack of studies assessing the mechanisms that play a role in the associations of dietary patterns and cancer. The main objective is to develop a protocol to identify,...
Evidence suggests that increased and excess fat mass, adiposity, is associated with increased colorectal cancer risk. There is also evidence that concentrations of many circulating proteins are altered in individuals with adiposity and colorectal cancer. Whether these proteins mediate the association between adiposity and colorectal cancer is not clear.
We use two-sample Mendelian...
Research on cancer, one of the most lethal diseases in the world today, is an expensive, complex process, usually carried out manually in laboratories. In this publication, we present CanGraph, a software solution that allows its users to annotate and interpret unknown metabolites by making use of five pre-existing databases (HMDB, SMPDB, DrugBank, ExposomeExplorer and Wikidata) and five...
Although alcohol is recognized as a type 1-carcinogen, prospective studies evaluating the association between alcohol consumption and the risk of pancreatic cancer (PC) have generally faced power limitation to generate consistent evidence among never smokers. Here, we evaluated the association as part of the Diet and Cancer Pooling Project, a large international consortium of prospective...
