Background
Obesity is a major risk factor for endometrial cancer (EC), but the underlying mechanisms are not well understood. Using proteomics and causal mediation analysis, we examined 155 circulating protein markers in 624 cases and 624 matched controls in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)...
Head and neck cancer (HNC) is the sixth most common cancer worldwide originating from oral cavity, nasopharynx, oropharynx, hypopharynx, and larynx causing 444,347 deaths in 2020. Although alcohol, tobacco, and human papillomavirus (HPV) are major risk factors for HNC, only a small fraction of high-risk individuals developed HNC implying a crucial role of genetic susceptibility in the disease...
1- Introduction
Alcohol use is associated with cancer development at various anatomical sites including oral cavity, and is responsible for ~13% of all cancers worldwide. Despite strong epidemiological evidence, the mechanisms of ethanol carcinogenicity in the oral cavity remain unclear. Ethanol’s main metabolite acetaldehyde (AcA) may play a crucial role in head and neck cancers by forming...
Cancer is thought to result from the gradual accumulation of genetic mutations in a cell. Environmental and lifestyle exposures to mutagenic agents and endogenous processes may cause mutations in normal cells. Collections of these cells (clones) harbouring driver mutations can exist in different tissues without ever transforming into cancer. However, recent evidence suggest that non-mutagenic...
Background and objectives: We undertook this study to estimate the number of cancer cases that could be prevented through decreasing the prevalence of opium use by 2035 in Iran, where 40% of the world opium is consumed.
Methods: The projection of the population attributable fraction (PAF) of cancers due to opium use was calculated using four data sources including (i) national cancer...
